Drivers are urged to avoid the A19 at Clifton, near Clifton Green, which is closed this morning (Wednesday, May 8) due to the collision.
Police on the scene told The Press one person was taken to hospital.
City of York Council said inbound traffic is being diverted around Clifton Green.
The AA said the road is blocked with heavy traffic both ways from Water Lane to Compton Street.
A police cordon is in place with multiple police cars and vans on the scene.
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